Hint #1: You might not have heard of this fruit before... this is where Google (or your favorite search engine) comes in handy
Hint #2: OERSIMMONS is such a weird entry...
Hint #3: "A fresh start" is a new beginning... there are six grid entries whose first letter can be changed to make a fruit
Hint #4: All these fruits begin with the letter P... OERSIMMONS --> Persimmons... NINEAPPLES --> Pineapples
Hint #5: "Dragon fruit" doesn't begin with a P... but it goes by another name that does (back to hint #1)