Hint 1: Did you notice that the grid is rectangular in shape - kinda like a painting?
Hint 2: Did you also notice the superfluous wording of some of the clues - particularly the ones containing "numbers"?
Hint 3: What about those numbers? What could they be indicating about the painting in the grid?
Hint 4: Using your finest artist brush (or Avery Hi-Liter), lightly color in the grid entries that correspond to those numbers. Then take a step back, and admire your work!
Hint 5: 49-Down49DMaterial used for framing most paintings[----] is more than just framing material. It's also the artist's last name.