Yet another Connections inspired puzzle! This should be fairly quick to see, but who knows. Whatever the case, follow the title and do not let it bug you.
I want to thank snood who helped me test this puzzle and made some great suggestions.
I would rate this:
Kitten

Calico
Persian
Puma
Lion
The Reveal:
The answers to clues 19, 21, 39, 57, and 59 could all have their first letter removed to form a bug name:
BLOUSE = LOUSE
SMITE = MITE
PANTS = ANTS
STICK = TICK
BROACH = ROACH
These bugs all had alternate clues; 9D, 64D, 66A, 32D and 26D
The first letters of those answers spelled ANNOY, the meta answer
For a graphic representation of the solve see:
Some nice DrTomesque cluing, I especially liked IRA.