My first cryptic! I owe my thanks to riotblob for playtesting this one before I published it and offering a lot of advice, especially when it comes to cryptic correctness. Much of their advice improved the puzzle, and some of it I chose not to follow, so if there's anything you dislike it's definitely my own fault!
5A: Very nice, but hard given that you need to identify two synonyms, make a deletion, and read [all over] as a container indicator. I don't think the crossword clue of [driven mad], which indicates a verb, quite matches up with ROAD-iE, though I love the idea of where it's going.
6A: Not sure why you've got [salesman] and [she]; makes it harder to see [not as she seems] as an anagram indicator.
1D: This is the kind of indirect anagram I'm most against. You need to change [chore] into ERRAND, delete the last letter, and THEN anagram it into a synonym for [did it again]. Again, if you're trying to make it really hard, this is the way to go.
2D: Not too many people use partial homophones, but this one's slick. [Appeal] is really nicely misdirecting here.
3D: I'd probably delete [the], but this is neat.
4D: I think this is trying to clue G with [note] (as in musical), but I don't know where UESS comes from. That looks like an indirect anagram of USES, but that would need to be [operates]. Apologies if I'm reading it wrong!