This puzzle is about the following paper: Chen, K. H., Boettiger, A. N., Moffitt, J. R., Wang, S., & Zhuang, X. (2015). Spatially resolved, highly multiplexed RNA profiling in single cells. Science.
I forgot to include the citation -- made this a while ago about a paper my friend was presenting at a journal club, so it's about a 12/10 on the "niche theme" scale