Nice grid. I like to pause these indie puzzles to look up stuff I'm not familiar with, such as Yayoi Kusama, the cinnamon roll meme, and that remarkable hot dog site.
"Beautiful ___ Too Good for This World, Too Pure" (The Onion headline)
45A
Org. that regulates Big Pharma and Big Farmer
47A
One less than trece
48A
Freudian term that becomes a waffle brand when you double one of the letters
49A
Tulle belt?
51A
Exams for lawyers-to-be: Abbr.
54A
"Do not ___ Go"
58A
With 66-Across, David Sedaris essay collection... or the appropriate time to do the beginning, middle, and end of 18-, 26-, and 41-Across, respectively
61A
Use an epee, maybe
62A
NBA person who calls the shots
63A
Lorde song that features the lyric "Even the comatose, they don't dance and tell"
65A
Word that Spongebob wrote in the style of an illuminated manuscript
66A
See 58-Across
72A
A snail's home and body
73A
Actress Thompson of "Thor: Ragnarok"
74A
"Cooking ___" (video game series)
75A
Tricks
76A
It sticks to Pan
77A
Freshly
Verticali
1D
Size up
2D
Spiral-shaped pasta
3D
Aware of the joke
4D
Egyptian viper
5D
Elsa's unmagical sister
6D
Ping-Pong necessity
7D
Sneaky "Dungeons & Dragons" adventurers
8D
"If you ask me," online
9D
Set ablaze
10D
Flight part between landings
11D
It sticks to pans
12D
Hound sound?
13D
"Say less."
14D
Uppermost, leftmost key on a MacBook
19D
"Honest" Lincoln
20D
Cone counterpart
25D
Singer Lovato who locked her sister Poot in a basement
27D
Arguably the most famous Cairn Terrier
28D
Measurement from wingtip to wingtip
29D
Door sign you notice after pushing doesn't work
30D
Second name in a candy duo
31D
Capital of Tennessee?
33D
Be's is 4, B's is 5
36D
Rear
38D
Angers
39D
"Ants on a ___" (peanut butter, celery & raisin snack I've never seen in real life)
41D
Actress Blanchett of "Thor: Ragnarok"
42D
Grp. that defends your rights
43D
Southwest plateau
44D
Casual stride
45D
"This situation is preferable", online
46D
"Obviously!"
50D
Too much to handle
52D
Yayoi Kusama, for one
53D
Itty bitty
55D
Paul Rudd Marvel character
56D
Word after color or pyramid
57D
Playground item made up of a verb in the present tense followed by that verb in the past tense
59D
Hollers
60D
Not on
61D
"This situation is not preferable", online
64D
A long way off
66D
Mind-reading, e.g.
67D
Org. for Devils and Ducks
68D
What you replace "Je" with to make that other spelling of Jeffrey