Hint #1: Ten entries have emojis
Hint #2: The central Across entry 40A is important. Note that the title is an example of one
Hint #3: Combine the nudges from 21A and 38D
Hint #4: You will need to alphabetize the anime titles, not the individual grid entries themselves, for example: "Cowboy Bebop" comes before "Fullmetal Alchemist"
Hint #5: The first words (not first letters) of the relevant clues in anime title order will ask you a question