The Canary Islands' most populous city, and one of the archipelago's two joint capitals (3,6)

The flower bud of Capparis spinosa, typically seen salted or pickled for consumption (5)

A system of classifying blood groups, or a genre of speculative fiction also known as omegaverse (3, init.)

1987 satirical science-fiction action film directed by Paul Verhoeven, or its title character depicted by Peter Weller (7)

First name shared by characters portrayed by Ryan Gosling, William Roache, and Aaron Stanton (3)

Biologically essential polymeric molecule that typically takes the form of a single helical strand (3, init.)

O₃, a pale blue gas with a pungent odour found in small concentrations throughout earth's atmosphere (5)

The dynastic name of the fifth and seventh Etruscan kings of Rome; or, that of Lucretia's assailant, the latter's son (7)

____ Szyslak, grouchy owner of the namesake tavern in The Simpsons (3)

The adult, developmentally mature stage of an insect's metamorphosis (5)

Japanese video game company with franchises including Sonic the Hedgehog and consoles including the Genesis (4)

Enclosed sporting or performance space whose name derives from the sand used in ancient examples to absorb blood (5)

New York rapper with the 1994 debut album illmatic (3)

'____ Blues', Lennon-penned parody song appearing on The White Album (3)

Mathemagical logical operator denoting a biconditional statement (3)

Queen ____, 'the fairies' midwife' in the words of Romeo and Juliet's Mercutio (3)

A chord of three notes, particularly one comprised of two stacked thirds (5)

Husband of Jezebel in the Biblical Book of Kings, and namesake of Melville's vengeful captain (4)

Mario that portrayed operatic tenor Enrico Caruso in a triple Oscar-nominated 1951 biopic (5)

Son of Kanga in the Winnie-the-Pooh stories (3)

Protagonist and original title of Beethoven's sole opera Fidelio (7)

Surname of Olivia who played Remy 'Thirteen' Hadley on House, or the Irish writer from whom she took her stage name (5)

1977 Steely Dan single from Aja (3)

In cricket, the opposite of 'leg' (3)

1966 William Shatner-led, Esperanto-language horror film, named after a folkloric sleep-demon (7)

An acronym of shock, surprise or excitement first attested in 1917 (3, init.)

Austrian composer Joseph, employed as the Esterházy family's sole Kapellmeister between 1766 and 1790 (5)

1854 Dickens novel set in the fictional Coketown (4,5)

Ophelia's brother in Hamlet, or father of Odysseus (7)

The second largest city in the Indian province of Gujarat, central to the diamond industry (5)

Fossilised tree resin, often worked as a gemstone (5)

'Old' in Quechua, as in the first word of a famous Inca citadel (5)

Any of a range of bitter plant-derived compounds named for their useful properties in soaps (7)

Eurodance project behind 1993 hit 'Rhythm of the Night' (6)

Wide-reaching Japanese media franchise founded by Satoshi Tajiri centering around the titular collectable creatures (7)

MLB team based in Dallas–Fort Worth–Arlington (7)

Adjective commonly used for a visiting team in a sports fixture (4)

Geologically abundant form of silicon dioxide known for its piezoelectric properties (6)

Counterpart to 'Death' in a noted 1817 Schubert art-song or the 1824 string quartet that derives its second-movement theme from it (6)

'Little' American singer known for hit dance song 'The Loco-Motion' (3)

British music corporation, or its flagship record label now owned by Universal (3, init.)

Cuban/Spanish actress de Armas, known for appearances in Blade Runner 2049 and Blonde (3)

Tommy _____, Welsh heavyweight boxer famous for his controversial 1937 world title challenge defeat against Joe Louis (4)

Australian-British media-mogul family whose Rupert established News Corporation in 1980 (7)

Shiny insect of the family Calliphoridae, particularly known for causing flystrike in livestock (7)

North Carolina's 'City of Oaks', named for the Elizabethan explorer behind the nearby lost colony of Roanoke (7)

An inhabitant of a borough; or, surname of the author of the Enderby novels (7)

Manitoba river that drains Lake Winnipeg; the second-longest river entirely within Canada (6)

Statuette awarded by the Academy of Motion Picture Arts and Sciences (5)

Public artwork and observation tower in London, England, designed by Anish Kapoor and Cecil Balmond; or, the eye-socket (5)

Surrey spa town famed for its mineral salts and equestrian racecourse (5)